99% White Powder Mutant-Selective Wz4002 CAS 1213269-23-8
Basic Info
Model No.: 1213269-23-8
Product Description
Model NO.: 1213269-23-8 Customized: Customized Suitable for: Elderly, Children, Adult Purity: >99% CAS: 1213269-23-8 Appearance: White Powder Delivery Mode: Express Specification: ISO9001 HS Code: 2933599090 Powder: Yes Certification: GMP, HSE, ISO 9001, USP, BP State: Solid Name: Wz4002 Mf: C25h27cln6o3 Packing: 10g/Foil Bag Trademark: Shuangbojie Origin: China 99% White Powder Mutant-selective WZ4002 CAS 1213269-23-8
1. WZ4002 Details:
Name:WZ4002
Synonyms:N-(3-(5-chloro-2-(2-methoxy-4-(4-methylpiperazin-1-yl)phenylamino)pyrimidin-4-yloxy)phenyl)acrylamide;N-[3-[[5-Chloro-2-[[2-methoxy-4-(4-methyl-1-piperazinyl)phenyl]amino]-4-pyrimidinyl]oxy]phenyl]-2-propenamide;WZ4002(HBr);N-{3-[(5-Chloro-2-{[2-Methoxy-4-(4-Methyl-1-piperazinyl)phenyl]aMino}-4-pyriMidinyl)oxy]phenyl}acrylaMide;N-[3-[5-chloro-2-[2-Methoxy-4-(4-Methylpiperazin-1-yl)anilino]pyriMidin-4-yl]oxyphenyl]prop-2-enaMide;N-[3-[[5-Chloro-2-[[2-methoxy-4-(4-methyl-1-piperazinyl)phenyl]amino]-4-pyrimidinyl]oxy]phenyl]-2-propenamide WZ 4002;WZ 4002 N-[3-[[5-Chloro-2-[[2-methoxy-4-(4-methyl-1-piperazinyl)phenyl]amino]-4-pyrimidinyl]oxy]phenyl]-2-propenamide
CAS:1213269-23-8
MF:C25H27ClN6O3
Appearance:White powder
Assay:99%
Solubility: DSMO 13 mg/mL Water
Usage:A novel mutant-selective EGFR kinase inhibitor of EGFRL858R and EGFRL858R/T790M with IC50s of 2 nM and 8 nM, respectively.
Packing:10g/foil bag
Storage: 2 years at -20 centigrade
2. WZ4002 Application:
In vitro: As a novel, mutant-selective EGFR inhibitor, WZ4002 is can inhibit EGFR(L858R) and EGFR(L858R/T790M) with IC50 of 2 nM and 8 nM..WZ4002 can inhibit widetype ERBB2 with an IC50 of 32 nM. WZ4002 inhibits EGFR, AKT and ERK1/2 phosphorylation in NSCLC cell lines.WZ4002 prevents EGFR kinase activity of recombinant L858R/T790M protein more potently than of WT EGFR, while the opposite is observed with HKI-272 and gefitinib.
In vivo: WZ4002 treatment results in significant tumor regressions compared to vehicle alone in both T790M containing murine models.
3. Recommend Products:
4. Our Advantages:
Rich experience
We specialize in this field for many years,our pharmaceutical raw materials exported to Overseas, to Europe,Africa,Asia, Americas and other country, and we have got very good feedback from our customers,and Established long friendly relations of cooperation.
Safest and fastest delivery
We have Adequate stock,and can arranged within 24 hours when receive the payment.Tracking number would be informed quickly after shipment.
We have special way could ship 2kg to 20tons products a time. We offer melting powder into liquid service.And ship the liquid in special bottles.
Good after-sales service
Tell the package update asap, and will try best solve when customer encountered various problems!
Contact us if you need more details on Wz4002. We are ready to answer your questions on packaging, logistics, certification or any other aspects about Lgd-4033、Gw501516. If these products fail to match your need, please contact us and we would like to provide relevant information.
1. WZ4002 Details:
Name:WZ4002
Synonyms:N-(3-(5-chloro-2-(2-methoxy-4-(4-methylpiperazin-1-yl)phenylamino)pyrimidin-4-yloxy)phenyl)acrylamide;N-[3-[[5-Chloro-2-[[2-methoxy-4-(4-methyl-1-piperazinyl)phenyl]amino]-4-pyrimidinyl]oxy]phenyl]-2-propenamide;WZ4002(HBr);N-{3-[(5-Chloro-2-{[2-Methoxy-4-(4-Methyl-1-piperazinyl)phenyl]aMino}-4-pyriMidinyl)oxy]phenyl}acrylaMide;N-[3-[5-chloro-2-[2-Methoxy-4-(4-Methylpiperazin-1-yl)anilino]pyriMidin-4-yl]oxyphenyl]prop-2-enaMide;N-[3-[[5-Chloro-2-[[2-methoxy-4-(4-methyl-1-piperazinyl)phenyl]amino]-4-pyrimidinyl]oxy]phenyl]-2-propenamide WZ 4002;WZ 4002 N-[3-[[5-Chloro-2-[[2-methoxy-4-(4-methyl-1-piperazinyl)phenyl]amino]-4-pyrimidinyl]oxy]phenyl]-2-propenamide
CAS:1213269-23-8
MF:C25H27ClN6O3
Appearance:White powder
Assay:99%
Solubility: DSMO 13 mg/mL Water
Usage:A novel mutant-selective EGFR kinase inhibitor of EGFRL858R and EGFRL858R/T790M with IC50s of 2 nM and 8 nM, respectively.
Packing:10g/foil bag
Storage: 2 years at -20 centigrade
2. WZ4002 Application:
In vitro: As a novel, mutant-selective EGFR inhibitor, WZ4002 is can inhibit EGFR(L858R) and EGFR(L858R/T790M) with IC50 of 2 nM and 8 nM..WZ4002 can inhibit widetype ERBB2 with an IC50 of 32 nM. WZ4002 inhibits EGFR, AKT and ERK1/2 phosphorylation in NSCLC cell lines.WZ4002 prevents EGFR kinase activity of recombinant L858R/T790M protein more potently than of WT EGFR, while the opposite is observed with HKI-272 and gefitinib.
In vivo: WZ4002 treatment results in significant tumor regressions compared to vehicle alone in both T790M containing murine models.
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| LGD-4033, Ligandrol | 1165910-22-4 | pharmacological profile similar to that of enobosarm, Ostarine,MK-2866 |
| GW501516, Cardarine | 317318-70-0 | For obesity, diabetes, dyslipidemia and cardiovascular disease |
| Andarine(S4) | 401900-40-0 | partial agonist, intended mainly for treatment of benign prostatic hypertrophy |
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| AICAR | 2627-69-2 | acts by entering nucleoside pools, significantly increasing levels of adenosine during periods of ATP breakdown |
4. Our Advantages:
Rich experience
We specialize in this field for many years,our pharmaceutical raw materials exported to Overseas, to Europe,Africa,Asia, Americas and other country, and we have got very good feedback from our customers,and Established long friendly relations of cooperation.
Safest and fastest delivery
We have Adequate stock,and can arranged within 24 hours when receive the payment.Tracking number would be informed quickly after shipment.
We have special way could ship 2kg to 20tons products a time. We offer melting powder into liquid service.And ship the liquid in special bottles.
Good after-sales service
Tell the package update asap, and will try best solve when customer encountered various problems!
Contact us if you need more details on Wz4002. We are ready to answer your questions on packaging, logistics, certification or any other aspects about Lgd-4033、Gw501516. If these products fail to match your need, please contact us and we would like to provide relevant information.
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