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New Anti-Progesterone Mifepristone CAS 84371-65-3 for Contraception

Basic Info

Model No.:  84371-65-3

Product Description

Model NO.: 84371-65-3 Customized: Non-Customized Suitable for: Adult Purity: >99% Molecular Formula: C29h35no2 Assay: 99%Min Density: 1.18 g/cm3 Delivery: Within 24 Hours After Payment Confirmed Supply Capacity: 50000kg/Month Specification: ISO9001 HS Code: 29224999 Powder: Yes Certification: ISO 9001, USP State: Solid CAS: 84371-65-3 Molecular Weight: 429.59 Melting Point: 195-198° C Shipping: TNT, UPS, DHL, EMS, Hkems, FedEx Payment: Western Union, Moneygram, T/T,Bitcoin Trademark: shuangbojie Origin: China New Anti-Progesterone Mifepristone CAS 84371-65-3 for Contraception

Synonyms: Estra-4, 9-dien-3-one, 11-[4-(dimethylamino)- phenyl]-17-hydroxy-17-(1-propynyl)-, (11a, - 17a)-Mifepristone; 17-beta-Hydroxy-11-beta-(4-dimethylaminophenyl-1)-17-alpha-(prop-1-ynyl)oestra-4, 9-dien-3-one
Inchi: InChI=1S/C29H35NO2/c1-5-15-29(32)16-14-26-24-12-8-20-17-22(31)11-13-23(20)27(24)25(18-28(26, 29)2)19-6-9-21(10-7-19)30(3)4/h6-7, 9-10, 17, 24-26, 32H, 8, 11-14, 16, 18H2, 1-4H3/t24-, 25+, 26-, 28-, 29-/m0/s1
CAS No.: 84371-65-3
MF: C29H35NO2
MW: 429.59
Purity: 99%min
Density: 1.18 g/cm3
Melting Point: 195-198° C
Boiling Point: 628.6 ° C at 760 mmHg
Refractive Index: 1.623
Flash Point: 334 ° C
Appearance: Pale Yellow Solid
Grade: Pharmaceutical Grade
Storage: Shading, confined preservation
Lead time: Within 12 hours upon receipt of payment
Delivery: EMS, DHL, TNT, FedEx, UPS
Usage: New anti-progesterone, and has anti-glucocorticoid activity, but not progesterone, estrogen, androgen and anti-estrogen activity. And progesterone receptor affinity 5-fold stronger than progesterone. For anti-early pregnancy, reminders by only pregnancy, fetal death, uterine induction of labor, etc.

Product description:
Mifepristone (or RU-486) is a synthetic steroid compound with both antiprogesterone and antiglucocorticoid properties. The compound is a 19-nor steroid with substitutions at positions C11 and C17 (17 beta-hydroxy-11 beta-[4-dimethylamino phenyl] 17 alpha-[1-propynyl]estra-4, 9-dien-3-one), which antagonizes cortisol action competitively at the receptor level.
Mifepristone is a progesterone receptor antagonist used as an abortifacient in the first months of pregnancy, and in smaller doses as an emergency contraceptive. It is also a powerful glucocorticoid receptor antagonist, and has occasionally been used in refractory Cushing's syndrome (due to ectopic/neoplastic ACTH/cortisol secretion).
Mifepristone was the first antiprogestin to be developed and it has been evaluated extensively for its use as an abortifacient.

Mifepristone can also be used in smaller doses as an emergency contraceptive; If taken after sex but before ovulation, it can prevent ovulation and so prevent pregnancy. In this role, a 10-mg dose is not as effective as the 600-mg dose, but has fewer side effects. Mifeprex and Mifegyne are only available in 200-mg tablets.
A review of studies in humans found that the contraceptive effects of the 10-mg dose were probably due mainly to its effects on ovulation, and not inhibition of implantation, but "the knowledge of the mechanism of action remains incomplete". Treatment with 200 mg of mifepristone changes steroid receptor expression in the Fallopian tube, inhibits endometrial development, and effectively prevents implantation.
Other medical applications of mifepristone studied in clinical trials include regular long-term use as an oral contraceptive, and treatment of HIV infection, uterine fibroids, endometriosis, major depression with psychotic features, bipolar depression and disorders causing cognitive dysfunction, post-traumatic stress disorder, chronic multisymptom illness, glaucoma, meningiomas, breast cancer, ovarian cancer, and prostate cancer.

Items of analysis Specification Results
Description Light Yellowish Crystalline Powder Light Yellowish Crystalline Powder
Identification the maximum absorption wavelength of 304nm, 260nm, and infrared absorption spectra were consistent with the control product. Conformity
Melting Point 192ºC~196ºC
Specific Rotation +124°~ +129°
+124°~ +129°
Single Impurity ≤0.5%
Total Impurity ≤1.0%
Loss On Drying ≤0.5%
Assay ≥98.5%
Sieve analysis ≤30μm



Mifeprex is used to end an early pregnancy that is not further along than 49 days (7 weeks) after the first day of your last menstrual period. MIFEPREX MUST NOT BE USED IN AN ATTEMPT TO END PREGNANCY BEYOND 7 WEEKS.

Mifepristone is used alone or in combination with misoprostol (Cytotec) to end an early pregnancy. Early pregnancy means it has been 49 days or less since your last menstrual period began. Mifepristone is in a class of medications called antiprogestational steroids. It works by blocking the activity of progesterone, a substance your body makes to help continue pregnancy.
Mifepristone is also available as another product (Korlym), which is used to control hyperglycemia (high blood sugar) in people with a certain type of Cushing's Syndrome in which the body makes too much of the hormone cortisol. This monograph only gives information about mifepristone (Mifeprex), which is used alone or in combination with another medication to end an early pregnancy.

Mifepristone is also sometimes used to end pregnancies when more than 49 days have passed since the woman's last menstrual period; as an emergency contraceptive after unprotected sexual intercourse ('morning-after pill'); to treat tumors of the brain, endometriosis (growth of uterus tissue outside the uterus), or fibroids (noncancerous tumors in the uterus); or to induce labor (to help start the birth process in a pregnant woman). Mifepristone can also be used in smaller doses as an emergency contraceptive; if taken after sex but before ovulation, it can prevent ovulation and so prevent pregnancy. In this role, a 10-mg dose is not as effective as the 600-mg dose, but has fewer side effects.

Related products:
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Cyproterone Acetate CAS: 427-51-0
Megestrol Acetate CAS: 595-33-5
Hydroxyprogesterone Caproate CAS: 630-56-8
Mifepristone CAS: 84371-65-3
Norgestimate CAS: 35189-28-7
Drospirenone CAS: 67392-87-4
19-Norethindrone acetate CAS: 51-98-9
Ethisterone CAS: 434-03-7
Allylestrenol CAS: 432-60-0
Pregnenolone CAS: 432-60-0
Levonorgestrel CAS: 797-63-7
Algestone Acetophenide CAS: 24356-94-3
Lynestrenol CAS: 52-76-6
Norethindrone CAS: 68-22-4
Norethisterone Enanthate CAS: 3836-23-5

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