High Purity Topical Anaesthesia Procaine Hydrochloride Procaine HCl 51-05-8

Model NO.: 51-05-8 Customized: Non-Customized Suitable for: Adult Purity: >99% Alias: Procaine HCl appearance: White Powder Shipping: EMS, DHL, TNT, FedEx, Hkems Delivery Time: Within 3-7 Working Days Specification: USP, EP standard Powder: Yes Certification: GMP, HSE, ISO 9001, USP State: Solid Product Name: Procaine Hydrochloride CAS: 51-05-8 Export Markets: Global Shipping Time: Within 8 Hours After Payment Comfirmed Trademark: SBJ Origin: China High Purity Topical Anaesthesia Procaine Hydrochloride Procaine HCl 51-05-8

Quick Detail:

Procaine is one of the ester-type local anesthetics, which is oldest and widely usedquick action local anesthetics with less toxicity. PROCAINE HYDROCHLORIDE is a Local Anesthetic of the ester type that has a slow onset and a short duration of action. It is mainly used for infiltration anesthesia, peripheral nerve block, and spinal block.

Basic information:

Product name:Procaine Hydrochloride
Other name:Procaine HCL
Chemical name: 4-Aminobenzoic acid 2-diethylaminoethyl ester hydrochloride
Assay:99%min.
CAS register number:51-05-8
EINECS:200-077-2
Molecular formula:C13H20N2O2.HCl
Molecular weight:272.77
Melting point:80-82°C
Grade: USP
Storage instructions: Store at room temperature.
Character: White crystal to powder, Melting point 154-158, Water solubility soluble.
Usage: Active Pharmaceutical Ingredient (API), Local anesthetic for infiltration anesthesia, nerve block, etc.

Related Local Anesthetic product:

Procaine/ Procaine Hydrochloride
Lidocaine/ Lidocaine Hydrochloride
Tetracaine/ Tetracaine Hydrochloride
Prilocaine Hydrochloride
Benzocaine/ Benzocaine hydrochloride
Ropivacaine Mesylate
paracetamol
Levobupivacaine Hydrochloride

Lidocaine base
Chemical Name: Lidocaine
Molecular Formula: C14H22N2O
Formula Weight: 234.34
CAS No.: 137-58-6
Pakcage: 25kg/drum
Usage: Local anesthetics

How it works?

Procaine Hydrochloride is the hydrochloride salt form of procaine, a benzoic acid derivative with local anesthetic and antiarrhythmic properties. Procaine binds to and inhibits voltage-gated sodium channels, thereby inhibiting the ionic flux required for the initiation and conduction of impulses. In addition, this agent increases electrical excitation threshold, reduces rate of rise of action potential and slows nerve impulse propagation thereby causing loss of sensation.

Application:

procaine hydrochloride, also called Novocain, or ,  synthetic organic compound used in medicine as a local anesthetic. Introduced in 1905 under the trade name , it became the first and best-known substitute for in local anesthesia. Generally used in a 1 to 10 percent saline solution, procaine hydrochloride is administered by injection for infiltration (area flooding as in dental anesthesia), nerve-block, spinal, and caudal anesthesia. Unlike , procaine is not toxic, addicting, or irritating. It has been displaced somewhat by the chemically related drugs lidocaine and mepivacaine, which produce prompter, more intense anesthesia.

Procaine hydrochloride is a salt of the compound Procaine. Procaine is a noted sodium channel blocker with a variety of inhibitory effects. In skeletal muscle, Procaine has been reported to inhibit calcium-induced calcium release (CICR). Procaine is also noted to act as a DNA methylation inhibitor and to cause demethylation and reactivation of methylation-silenced genes such as RARβ and GSTP1. WIF-1 is noted to be reactivated in a cancer cell line and to downregulate the Wnt canonical pathway. In studies utilizing a neuroblastoma cell line (SHEP), Procaine is reported to induce neuronal apoptosis in a manner correlated with lipid solubility of the compound. In an adult mouse muscle cell line (HEK293), the presence of procaine is reported to potently inhibit nicotinic acetylcholine receptors. Procaine is available alone (sc-296134) and in its salt form as Procaine HCl.

COA:

Product name	Procaine Hydrochloride
Appearance	White crystalline powder
Assay (C13H20N2O2·HCl)	99.0% to 101.0%	99.5%
Solution Appearance	Clear and colorless	Confirm
PH Value	4.0~5.5	4.35
Related impurities	impurity A:≤0.01%	0.002%
	Single unspecified impurity: ≤0.1%	0.03%
	Total impurity: ≤0.5%	0.19%
Heavy Metal	≤5ppm	<5ppm
Water	5.5%~7%	6.33%

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Product Categories : Local Anesthetic