2mg/Vial Pentadecapeptide Bpc 157 (Body Protection Compound 157) Peptide
Model No.: Pentadecapeptide BPC-157 (2mg)
Pentadecapeptide BPC 157 Profile:
Product Name: Pentadecapeptide BPC 157
Unit Size: 2mg/vial
Synonyms: Bpc 157, Bpc-157, Body protection compound 157
Molecular Formula: C62H98N16O22
Molecular Weight : 1419.53552
Sequence: Gly-Glu-Pro-Pro-Pro-Gly- Lys-Pro-Ala-Asp-Asp-Ala-Gly-Leu-Val
Purity: ≥99% (HPLC)
Physical State: White Lyophilized Powder
Solubility: Soluble in water or 1% acetic acid
Source: Chemical Synthesis
Storage: Lyophilized BPC 157 is stable at room temperature for 90 days,however it should be stored
in a freezer below -8C for any extended period of time. After reconstituting BPC 157 should be
refrigerated at temperatures not to exceed 36 F.
Payment &Shipping Terms:
Mini Order: 10 vials
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Lead Time: Within 12 hours after payment confirmed
Delivery: 3-7 days / Door-to-Door
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Supply Ability: 9,000 vials/month
Pentadecapeptide BPC 157 Description and Applications:
Pentadecapeptide BPC 157, composed of 15 amino acids, is a partial sequence of body protection compound (BPC) Pentadecapeptide BPC 157, composed of 15 amino acids, is a partial sequence of body protection compound (BPC) that is discovered in and isolated from human gastric juice.
The promoting effect of pentadecapeptide BPC 157 on tendon healing involves tendon outgrowth, cell survival, and cell migration. Stable gastric pentadecapeptide BPC 157 (GEPPPGKPADDAGLV, M.W. 1419) may be the new drug stable in human gastric juice, effective both in the upper and lower GI tract, and free of side effects.
BPC 157, in addition to an antiulcer effect efficient in therapy of inflammatory bowel disease (IBD)(PL 14736) so far only tested in clinical phase II, has a very safe profile, and exhibited a particular wound healing effect. It also has shown to interact with the NO-system, providing endothelium protection and angiogenic effect, even in severely impaired conditions (i.e., it stimulated expression of early growth response 1 gene responsible for cytokine and factor generation and early extracellular matrix (collagen) formation (but also its repressor nerve factor 1- A binding protein-2)), important to counteract severe complications of advanced and poorly controlled IBD. Hopefully, the lessons from animal studies, particularly advanced intestinal anastomosis healing, reversed short bowel syndrome and fistula healing indicate BPC 157s high significance in further IBD therapy. Also, this supportive evidence (i.e., no toxic effect, limit test negative, LD1 not achieved, no side effect in trials) may counteract the problems commonly exercised in the use of peptidergic agents, particularly those used
on a long-term basis.
Pentadecapeptide BPC 157, composed of 15 amino acids, is a partial sequence of body protection compound (BPC) that is discovered in and isolated from human gastric juice. Experimentally it has been demonstrated to accelerate the healing of many different wounds, including transected rat Achilles tendon. This study was designed to investigate the potential mechanism of BPC 157 to enhance healing of injured tendon. The outgrowth of tendon fibroblasts from tendon explants cultured with or without BPC 157 was examined. Results showed that BPC 157 significantly accelerated the outgrowth of tendon explants. Cell proliferation of cultured tendon fibroblasts derived from rat Achilles tendon was not directly affected by BPC 157 as evaluated by MTT assay. However, the survival of BPC 157-treated cells was significantly increased under the H2O2 stress. BPC 157 markedly increased the in vitro migration of tendon fibroblasts in a dose-dependent manner as revealed by transwell filter migration assay. BPC 157 also dose dependently accelerated the spreading of tendon fibroblasts on culture dishes. The F-actin formation as detected by FITC-phalloidin staining was induced in BPC 157treated fibroblasts. The protein expression and activation of FAK and paxillin were determined by Western blot analysis, and the phosphorylation levels of both FAK and paxillin were dose dependently increased by BPC 157 while the total amounts of protein was unaltered. In conclusion, BPC 157 promotes the ex vivo outgrowth of tendon fibroblasts from tendon explants, cell survival under stress, and the in vitro migration of tendon fibroblasts, which is likely mediated by the activation of the FAK-paxillin pathway.
NBSP was responsible for pituitary stimulation. In 1999 researchers Goa and Prakash checked sermorelin GH as provocative tasting method for deficiency of endogenous G-hormone. The most known features of this research compound are increasing lean muscular tissue mass, reducing fat, increasing bone tissue density and even enhancing functioning of immune system. It complies with certain amino-segment of natural long-chained GHrh. Sermorelin helps to convert exceeded volume of GH by liver into IGF-1.
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