Pharmaceutical Raw Materials Cabergoline Used to Parkinson′s Disease CAS 81409-90-7

Model NO.: 81409-90-7 Customized: Non-Customized Suitable for: Adult Purity: >99% Mf: C26h37n5o2 MP: 102-104ºC Appearance: White Crystalline Powder Payment: Western Union, Money Gram, T/T Trademark: Shuangbojie Origin: Shenzhne, China Powder: Yes Certification: ISO 9001, USP State: Solid CAS: 81409-90-7 MW: 451.6 Assay: 99% Delivery Time: Within 24 Hours Upon Receipt of Payment Grade: Pharmaceutical Grade Specification: ISO9001, GMP HS Code: 29152990 Pharmaceutical Raw Materials Cabergoline Used to Parkinson's Disease CAS 81409-90-7

Cabergoline
Alias: Dostinex; 6-allyl-n-[3-(dimethylamino)propyl]-n-(ethylcarbamoyl)ergoli
ne-8-carboxamide;CABERGOLINE;(8-beta)-(2-propenyl);n-(3-(dimethylamino)propyl)-n-((ethylamino)carbonyl)-6-ergoline-8-carboxamid;FCE-21336,Cabaser,Dostinex;(8b)-N-[3-(Dimethylamino)propyl]-N-[(ethylamino)carbonyl]-6-(2-propen-1-yl)- ergoline-8-carboxamide;Cabaser;Dostine
Purity: 99%
CAS: 81409-90-7
MF: C26H37N5O2
MW: 451.6
Melting Point: 102-104ºC
Chemical properties: Cabergoline is a white powder soluble in ethyl alcohol, chloroform, and DMF, and insoluble in water
Usage: Treatment of hyperprolactinemia, either idiopathic or due to pituitary adenomas. Investigational: Shrink tumors in clients with microprolactinoma or macroprolactinoma. Parkinson's disease. Normalize androgen levels and improve menstrual cyclicity in polycystic ovary syndrome.

Product introduction:
This medication is used to treat high levels of prolactin hormone in your body. High levels of prolactin in women can cause symptoms such as unwanted breast milk and missed periods and can cause difficulty becoming pregnant. High levels of prolactin in men can cause symptoms such as enlarged breasts and decreased sexual ability/desire. Cabergoline is an ergot medication and works by blocking the release of prolactin from the pituitary gland.

Description:
Cabergoline is an ergot medication and works by blocking the release of prolactin from the pituitary gland.
Dostinex is used to treat Parkinson's disease, to prevent women producing milk when they want to stop breast feeding(hyperprolactinemia), Cabergoline can lower prolactin levels in patients with a pituitary tumor. Cabergoline is also sometimes used to help men with sexual dysfunction.

Usage:
The biggest reason why Cabergoline is admired by amateur and professional athletes is because it helps them reduce or eliminate the risks associated with excess prolactin that is common with use of harsh and aromatizable steroids like Trenbolone and Deca Durabolin. Furthermore, this drug is also useful for treating sexual dysfunction caused by excess prolactin besides gaining an erection between orgasms and reducing recovery time after intense workouts or weight training and strength training exercises. In addition to these advantages, the use of Dostinex is equally beneficial to combat estrogenic side effects such as oily skin, acne, gynecomastia, and bloating and treating health complications like galactorrhea and sexual dysfunction. It is also routinely indicated to patients with Parkinson's disease as it has the potential to work on information pathways and nervous system of the body. Dostinex is also admired for its ability to make athletes feel 'full' that helps in minimizing food cravings without dieting discomfort.
 

use	adjunctive therapy of prolactin-producing pituitary gland tumors (prolactinomas);
	hyperprolactinemia
	treatment of uterine fibroids.
	monotherapy of Parkinson's disease in the early phase;
	combination therapy, together with levodopa and a decarboxylase inhibitor such as carbidopa, in progressive-phase Parkinson's disease;
	in some countries also: ablactation and dysfunctions associated with hyperprolactinemia (amenorrhea, oligomenorrhea, anovulation, nonpuerperal mastitis and galactorrhea);
	Cushing's disease - cabergoline may be used to lower ACTH levels and cause regression of ACTH producing pituitary adenomas;
	adjunctive therapy of acromegaly, cabergoline has low efficacy in suppressing levels and is highly efficient in suppressing hyperprolactinemia that is present in 20-30% of acromegaly cases;
	and prolactin are similar structurally and have similar effects in many target tissues, therefore targeting prolactin may help symptoms when hormone secretion can not be sufficiently controlled by other methods;

Specification:

Item	Specifications	Results
Description	White or almost white crystalline powder	Conform
Identity	1,IR complies	Conform
	2,X-Ray complies	Conform
	3,HPLC complies	Conform
Optical rotation	-77.0	-78.0
Loss on drying	Not more than 0.5%	0.32%
Related substances	1,Cabergolin Imp A no more than0.15%	0.05%
	2,Allylamide no more than 0.10%	0.03%
	3,Allyl DHLA no more than 0.15%	0.06%
	4,Cabergoline oxide no more than 0.10%	0.04%
	5,Other impurities individually no more than 0.10%	0.03%
	6,Total no more than 0.50%	0.21%
Assay(HPLC)	98.0%~102.0%(recalculated on anhydrous basis)	99.4%
Residual solvents	1,Dichloromethane no more than 100ppm	15ppm
	2,Acetone no more than 200ppm	15ppm
	3,Tert-butylmethylether no more than 200ppm	11ppm
	4,Xylene no more than 1500ppm	135ppm
	5,Heptane no more than 1000ppm	20ppm
Residue on ignition	No more than0.10%	0.03%
Heavy metals	No more than 20ppm	1ppm
Particle size	90% of particles no more than 80um	Conform
Bulk density	0.20~0.35g/cm3	0.33g/cm3
Conclusion	The results conforms with EP6.0/USP30 standard.

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