Model No.: CAS 4759-48-2
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|Product Categories||Antibiotics;Organic acids;APIs;Intermediates & Fine Chemicals;Pharmaceuticals;Retinoids;API;BUSPAR;Other APIs;intermediates|
|Stability||Stable, but probably air and light sensitive. Combustible. Incompatible with strong oxidizing agents.|
|Appearance||Yellow or orange crystalline powder|
|Package||100g / Aluminum foil bag|
|Usage||5HT1a receptor agonist, Anxiolytic; Used as a treatment for severe acne. Presently being studied in conjuction with the treatment of photoaged skin.|
Isotretinoin Test Report(COA):
|CAS No.||4759-48-2||Outer Packing||100GAluminum foil bag|
|Production date||2015/09/21||Shelf life||2017/09.20|
|Items of analysis||Specification||Results|
|Description||Yellow or orange crystalline powder||Complies|
|Loss on drying||≤0.5%||0.02%|
|Residue on ignition||≤0.1%||0.02%|
|Assay||98.0%~102.0 %( Calculated on the dried basis)||100%|
Description and Application:
Isotretinoin is the acid form of vitamin A and is also known as all-trans retinoic acid or ATRA. It is a drug commonly used to treat acne vulgaris and keratosis pilaris. It is available as a cream or gel It is also used to treat acute promyelocytic leukemia, and is sold for this indication by Roche under the brand name Vesanoid. It is also available as a generic.
Its success in treating acute promyelocytic leukemia was a major breakthrough in the treatment of this type of leukemia.It works in APL because the majority of cases involve a chromosomal translocation of chromosomes 15 and 17, which causes genetic fusion of the retinoic acid receptor gene to the promyelocytic leukemia gene. This fusion PML-RAR protein is responsible for preventing immature myeloid cells from differentiating into more mature cells. This block in differentiation is thought to cause leukemia. ATRA acts on PML-RAR to lift this block, causing the immature promyelocytes to differentiate to normal mature blood cells thus decreasing promyelocytes.
Isoretinoin; Isotrex; Treatment of Acne; Pharmaceutical Raw Materials:
1. Isotretinoin is used to treat severe cystic acne (also known as nodular acne) that has not responded
to other treatment (e.g., benzoyl peroxide or clindamycin applied to the skin or tetracycline or minocycline taken by mouth).
2. Isotretinoin belongs to a class of medicine known as retinoids. It works by decreasing facial oil
3. Isoretinoin, also known as 13-cis retinoic acid, is a medication primarily used to treat cystic acne.
4. Rarely, it is also used to prevent certain skin cancers (squamous-cell carcinoma), and in the treatment of other cancers. It is used to treat harlequin-type ichthyosis, a usually lethal skin disease, and lamellar ichthyosis. It is a retinoid, meaning it is related
to vitamin A, and is found in small quantities naturally in the body.
5. Isotretinoin is primarily used as a treatment for severe acne. The most common adverse effects are a
transient worsening of acne (lasting 2-3 weeks), dry lips (cheilitis), dry and fragile skin, and an increased susceptibility to sunburn.
Isotretinoin is used primarily for severe cystic acne and acne that has not responded to other treatments. Acne treatment usually begins with topical retinoids (e.g.tretinoin, adapalene), in combination with topical antibiotics (e.g. clindamycin, erythromycin) or antiseptics (e.g. benzoyl peroxide-containing preparations), followed by oral antibiotics (e.g. doxycycline or minocycline).
In women a cyproterone acetate-containing contraceptive pill can be useful if there are no contraindications. In cases of hormonal acne, such as in women in their 20s and 30s with cyclical acne, often a course of isotretinoin can permanently improve acne obviating the need for lifelong hormonal manipulation.
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Product Categories : Pharmaceutical Intermediates
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