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USP Isotretinoin CAS 4759-48-2 for Better Skin

Basic Info

Model No.:  CAS 4759-48-2

Product Description

Model NO.: CAS 4759-48-2 Customized: Customized Suitable for: Adult Purity: >99% CAS: 4759-48-2 Stock and Sample: Mass in Stock Now/ Sample Available Delivery: All Express Modes(Safe and Effecient) Trademark: SBJ Origin: China Powder: Yes Certification: ISO 9001, USP State: Solid Product Name: Isotretinoin (USP34) Advantages: 14 Years Manufacturer / Lowest Price Lead Time: Within 12 Hours After Payment Confirmed Shipping: 3-7 Days(Door-to-Door) Specification: USP/BP/EP HS Code: 3001200020 USP Isotretinoin CAS 4759-48-2 for Photoaged Skin and Severe Acne Anxiolytic
Attention: China 14 years old Manufacturer direct selling; Gold Member, Gold Quality; Lowest price served; Mass and plenty in stock now ; Sample and COA are available at any time; Prompt shipment after payment confirmed; Re-send policy; 5% discount for second same order.
Quick Detail:
Product Name Isotretinoin
Synonyms 13-cis-ra;13-cis-retinoicaci;13-ra;Isoretinoin;isotrex;neovitaminaacid;ro-4-3780
CAS 4759-48-2
MF C20H28O2
MW 300.44
EINECS 225-296-0
Product Categories Antibiotics;Organic acids;APIs;Intermediates & Fine Chemicals;Pharmaceuticals;Retinoids;API;BUSPAR;Other APIs;intermediates
Water Solubility  Insoluble
Stability Stable, but probably air and light sensitive. Combustible. Incompatible with strong oxidizing agents.
Appearance Yellow or orange crystalline powder
Assay 100%
Standard USP34
Package 100g / Aluminum foil bag
Mini Order 100g
Usage 5HT1a receptor agonist, Anxiolytic; Used as a treatment for severe acne. Presently being studied in conjuction with the treatment of photoaged skin.

 Isotretinoin Test Report(COA):
Product name Isotretinoin
CAS No. 4759-48-2 Outer Packing 100GAluminum foil bag
Production date 2015/09/21 Shelf life 2017/09.20
Standard adopted USP34
Items of analysis Specification Results
Description Yellow or orange crystalline powder Complies
Identification Complies Complies
Loss on drying ≤0.5% 0.02%
Residue on ignition ≤0.1% 0.02%
Heavy metals ≤0.002 <0.002%
Tretinoin ≤1.0% 0.1%
Assay 98.0%~102.0 %( Calculated on the dried basis) 100%
Conclusion Qualified

Description and Application:

Isotretinoin is the acid form of vitamin A and is also known as all-trans retinoic acid or ATRA. It is a drug commonly used to treat acne vulgaris and keratosis pilaris. It is available as a cream or gel It is also used to treat acute promyelocytic leukemia, and is sold for this indication by Roche under the brand name Vesanoid. It is also available as a generic.
Its success in treating acute promyelocytic leukemia was a major breakthrough in the treatment of this type of leukemia.It works in APL because the majority of cases involve a chromosomal translocation of chromosomes 15 and 17, which causes genetic fusion of the retinoic acid receptor gene to the promyelocytic leukemia gene. This fusion PML-RAR protein is responsible for preventing immature myeloid cells from differentiating into more mature cells. This block in differentiation is thought to cause leukemia. ATRA acts on PML-RAR to lift this block, causing the immature promyelocytes to differentiate to normal mature blood cells thus decreasing promyelocytes.

Isoretinoin; Isotrex; Treatment of Acne; Pharmaceutical Raw Materials:
1. Isotretinoin is used to treat severe cystic acne (also known as nodular acne) that has not responded 
to other treatment (e.g., benzoyl peroxide or clindamycin applied to the skin or tetracycline or minocycline taken by mouth).
2. Isotretinoin belongs to a class of medicine known as retinoids. It works by decreasing facial oil 
(sebum) production.
3. Isoretinoin, also known as 13-cis retinoic acid, is a medication primarily used to treat cystic acne.
4. Rarely, it is also used to prevent certain skin cancers (squamous-cell carcinoma), and in the treatment of other cancers. It is used to treat harlequin-type ichthyosis, a usually lethal skin disease, and lamellar ichthyosis. It is a retinoid, meaning it is related 
to vitamin A, and is found in small quantities naturally in the body.
5. Isotretinoin is primarily used as a treatment for severe acne. The most common adverse effects are a 
transient worsening of acne (lasting 2-3 weeks), dry lips (cheilitis), dry and fragile skin, and an increased susceptibility to sunburn.
Isotretinoin is used primarily for severe cystic acne and acne that has not responded to other treatments. Acne treatment usually begins with topical retinoids (e.g.tretinoin, adapalene), in combination with topical antibiotics (e.g. clindamycin, erythromycin) or antiseptics (e.g. benzoyl peroxide-containing preparations), followed by oral antibiotics (e.g. doxycycline or minocycline).
In women a cyproterone acetate-containing contraceptive pill can be useful if there are no contraindications. In cases of hormonal acne, such as in women in their 20s and 30s with cyclical acne, often a course of isotretinoin can permanently improve acne obviating the need for lifelong hormonal manipulation.

Packaging & Delivery Service:

1. Sufficient stock, to delivery promptly at the very day when receiving the payment.
2. Sophisticated and professional logistic agent.
3. Well-trained and disciplined packing team. Unique ways to ship goods to your destination. Fast and discreet shipment could be arranged for customs pass Guaranteed.
4. Packing pictures and tacking code are provided within 12 hours after receiving the payment. Updated tracking information will be provided every other day.
5. After-sale service: Any questions or problems after receiving the product, please feel free to contact us. Problems would be solved immediately.

Our Advantages:

1. Quality guarantee: we are a  leading professional factory in China special in pharmaceuticals (featured anesthetics, steriods, and peptides) for more than 14 years. Our product sexported to all over the world.
2. Discreet packing: The best-suited package would be selected to pass customs 100% guaranteed. The package updates would be closely tracked and timely informed. Once any problem found, the package would be reshipped for you.
3. Alternative delivery ways: by land, by air, by sea, by express(FedEx,UPS,DHL,EMS  etc.). The most cost-effecient  forwarder would be recommanded.
4. Considerate after-service: 24/7 at service for you. Any problem would be valued and solved ASAP.
5. COA (by  HPLC) and sample are available at any time.

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Product Categories : Pharmaceutical Intermediates