USP Minoxidil High Purity Minoxidil CAS 38304-91-5 Pharma Raw Material Promoting Hair Regrowth
Model No.: Minoxidil
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|Product Categories||API;Intermediates & Fine Chemicals;Pharmaceuticals;API's;Potassium channel;Heteroctcles;Bases & Related Reagents;Nitric Oxide Reagents;Nucleotides;ROGAINE;Other APIs|
|Appearance||White crystalline powder|
|Shelf life||3 years|
|Usage||1, Antihypertensive, anti alopecia agent |
2, A selective ATP dependent K+ (Kir6) channel activator
3, Used as an antihypertensive and anti alopecia agent. Minoxidil activates ATP-activated K+ channels
An antihypertensive vasodilator medication:
Minoxidil is an antihypertensive vasodilator medication also claiming to slow or stop hair loss and promote hair regrowth. It is available over the counter for treatment of androgenic alopecia, among other baldness treatments, but measurable changes, if experienced, disappear within months after discontinuation of treatment.
Minoxidil was first sold as a drug for high blood pressure and was noted to have the interesting side-effect of increased body hair-growth, or in some cases, significant hair loss. Treatments for baldness and hair loss usually include a 5% concentration solution that is designed for men, whereas the 2% concentration solutions are designed for women.
Minoxidil Test Report(COA):
|Product Name||Minoxidil||Lot no.||20140407|
|MFG. Date||2014.04.07||Report Date||2014.04.08|
|Test basis||USP30 standard||EXP.Date||2017.04.06|
|Test Items||Specification||Test Results|
|Characters||Off White or almost white crystalline powder||Off White or almost white crystalline powder|
|Loss on drying||≤0.5%||0.17%|
|Residue on ignition||≤0.5%||0.05%|
|Organic volatile impurities||Accord with USP30||Accord with USP30|
|Conclusion||Conforms to USP30 standards|
Description and Application:
Minoxidil is an antihypertensive vasodilator medication. It also slows or stops hair loss and promotes hair regrowth in some people. Now off-patent, it is available over-the-counter for the treatment of androgenic alopecia.
Minoxidil, applied topically, is widely used for the treatment of hair loss. It is effective in helping promote hair growth in both males and females with androgenic alopecia.About 40% of men experience hair regrowth after 3-6 months. Minoxidil must be used indefinitely for continued support of existing hair follicles and the maintenance of any experienced hair regrowth. It is the only topical product that is FDA approved for androgenic hair loss Treatments usually include a 5% concentration solution that is designed for men, and a 2% concentration solution for women.
The drug is available in the United Kingdom over-the-counter.
Its effect in people with alopecia areata is unclear.
Minoxidil is a clinical oral medication for lowering blood pressure , also known as minoxidil,piperazine pyrimidine diamine, buck fixed , Minoxidil blood given , are potassium channel opener , can direct relaxation of vascular smooth muscle, there is a strong expansion of the role of small arteries , the peripheral resistance decreased , blood vessels expand, blood pressure , and had no effect on the capacitance vessels , it can promote venous return . Meanwhile, the reflex regulation and positive frequency effect, can increase cardiac output and heart rate , but does not cause orthostatic
hypotension. Clinic for refractory hypertension and renal hypertension treatment. Can also be used for other antihypertensive drugs ineffective severe hypertension , but the need to avoid sodium retention diuretics and β -blockers can be combined to make increased efficacy , adverse reactions decreased.
Mechanism of action
The mechanism by which minoxidil promotes hair growth is not fully understood. Minoxidil is a potassium channel opener, causing hyperpolarization of cell membranes. Minoxidil is less effective when there is a large area of hair loss. In addition, its effectiveness has largely been demonstrated in younger men who have experienced hair loss for less than 5 years. Minoxidil use is indicated for central (vertex) hair loss only. Minoxidil is also a vasodilator.Hypothetically, by widening blood vessels and opening potassium channels, it allows more oxygen, blood, and nutrients to the follicle. This may cause follicles in the telogen phase to shed, which are then replaced by thicker hairs in a new anagen phase. Minoxidil is a pro-drug activated by sulfation via the sulfotransferase (SULT1A1). Several studies demonstrated that the activity of sulfotransferase in hair follicles predict minoxidil response in the treatment of hair loss.Two clinical studies are being conducted in the US for a medical device that may allow patients to determine if they are likely to fail minoxidil therapy.
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|Lead time||Within 12 hours upon receipt of payment|
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|Shipping time||Average 6 working days (Door-to-Door)|
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Packaging & Delivery Service:
1. Sufficient stock, to delivery promptly at the very day when receiving the payment.
2. Sophisticated and professional logistic agent.
3. Well-trained and disciplined packing team. Unique ways to ship goods to your destination. Fast and discreet shipment could be arranged for customs pass Guaranteed.
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1. Quality guarantee: we are a leading professional factory in China special in pharmaceuticals (featured anesthetics, steriods, and peptides) for more than 14 years. Our product sexported to all over the world.
2. Discreet packing: The best-suited package would be selected to pass customs 100% guaranteed. The package updates would be closely tracked and timely informed. Once any problem found, the package would be reshipped for you.
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5. COA (by HPLC) and sample are available at any time.
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Product Categories : Pharmaceutical Intermediates
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